Interactions between Herbal and Conventional Medicines: the Role of Cytochrome P450 Enzymes and P-glycoprotein
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چکیده
The extent of herb-drug interactions (H-DIs) is still largely unknown, although the use of herbal medicines among the general public is increasing. The theoretical and clinical evidence for some important H-DIs is presented, together with an explanation of pharmacodynamic interactions and pharmacokinetic effects involving P-glycoprotein and cytochrome P450 enzymes. Currently, research is being undertaken to identify potential interaction problems by means of in vitro and in vivo experimental methods; these, together with the most important H-DI’s are summarised.
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تاریخ انتشار 2006